William R. Dean as Additional Voices (voice)
John DeMita as Teacher (segment "Kid's Story") (voice)
Debi Derryberry as Kid (segment "The Second Renaissance, Part II") (voice)
John Di Maggio as Crew Man (segment "Final Flight of the Osiris") / Kaiser (segment "Program") (voice)
Alex Fernandez as Tom (segment "World Record") (voice)
Jack Fletcher as Townsperson (segment "Beyond") / Sandro (segment "Matriculated") (voice)
Julia Fletcher as The Instructor (segments "The Second Renaissance, Parts I&II")
Bette Ford as Old Woman (segment "Final Flight of the Osiris") (voice)
Rick Gomez as Pilot (segment "Final Flight of the Osiris") (voice)
Tom Kenny as Operator (segment "Final Flight of the Osiris") (voice)
Phil LaMarr as Duo (segment "Program")
Tress MacNeille as Housewife / Kenny (segment "Beyond") (voice)
Matt McKenzie as Agent #1 (segment "World Record") / Agent (segments "Beyond" and "A Detective Story") (voice)
Carrie-Anne Moss as Trinity (segments "Kid's Story" and "A Detective Story")
Keanu Reeves as Neo (segment "Kid's Story")
Kevin Michael Richardson as Thadeus (segment "Final Flight of the Osiris") / Cop (segment "Kid's Story") / Agent #2 (segment "World Record") (voice)
Rodney Saulsberry as Chyron (segment "Matriculated") (voice)
Dwight Schultz as Townspeople, Policeman, Exterminators (segment "Beyond") / Nonaka (segment "Matriculated") / Additional voice (segments "The Second Renaissance, Part I&II") (voice)
Allison Smith as Reporter (segment "World Record") (voice)
Kath Soucie as Pudgy / Masa / Sara (segment "Beyond") (voice)
Tara Strong as Crew Woman (segment "Final Flight of the Osiris") / Nurse (segment "World Record") / Misha (segment "Beyond") (voice)
Jill Talley as Mother / Additional voice (segments "The Second Renaissance, Parts I&II") / Townsperson (segment "Beyond") (voice)
James Arnold Taylor as Ash (segment "A Detective Story")
John Wesley as Dan's Dad (segment "World Record") (voice)
Victor Williams as Dan (segment "World Record") (voice)
Rick Gomez
as Pilot (segment "Final Flight of the Osiris")
(voice)
